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Principal Scientist Medicinal Chemistry

Status: Archived
CompanyBristol Myers Squibb
LocationSan Diego, California
How to Apply

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Job Description

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.


Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more:



When you join BMS, you are joining a diverse, high-achieving team united by a common mission. 


Bristol Myers Squibb encompasses a broad range of disciplines to enable a robust pipeline of drug candidates aimed at serious diseases.  Chemistry is a core capability in Small Molecule & Drug Discovery with innovative scientists working in medicinal chemistry, radiochemistry, analytical chemistry, and large-scale synthesis.  Within SMDD our Lead Discovery and Optimization (LDO) team is responsible for high throughput screening, compound storage and distribution, primary assays to support discovery programs, and compound profiling to explore drug liabilities in vitro.   LDO scientists discover and adopt cutting edge assay technologies that utilize state-of-the-art automation to drive speed and efficiency.  Our Molecular Structure and Design team embraces novel approaches to computer-aided drug design, machine learning, and structural biology.  The integration of these disciplines provides a seamless and highly interactive environment for discovery scientists to learn, develop, and innovate.  Working in partnership with our disease area experts in the Thematic Research Centers provides an exciting pathway to discover and deliver medicines to patients in need.


Medicinal Chemistry – Principal Scientist

We are seeking an exceptionally talented and highly motivated medicinal chemist who is passionate about joining our fast-paced medicinal chemistry group in the pursuit of discovering innovative therapies in Oncology. The candidate will have demonstrated an ability to design new synthetic targets independently and in a hypothesis-driven manner based on emerging SAR data. The candidate should have relevant supervisory experience with internal direct reports as well as external CROs. Candidates must have experience in the independent design and execution of multistep syntheses of complex organic molecules using modern organic chemistry. Excellent hypothesis driven problem-solving skills and a thorough understanding of medicinal chemistry principles, synthetic methods, and reaction mechanisms are required. Excellent oral and written communication skills and a desire to work in a collaborative team environment are required. A track record of innovation documented through co-inventorship on issued patents and authorship of publications in peer-reviewed journals is necessary.  A strong proficiency in fundamental aspects of drug discovery and demonstrated ability to lead or co-lead multi-disciplinary discovery programs and advancing them to critical milestones is preferred. Knowledge in E3 ligase and UPS biology is a plus as protein homeostasis is one of the fundamental research engines at BMS delivering therapeutics to patients. Not being bound by therapeutic modality creates a very dynamic, exciting and creative environment where the successful chemist will interface with an excellent team of scientists in biology, biochemistry, structural biology, computational biology and translational development.


Basic Qualifications:

Bachelor’s Degree and 8+ years of academic or industry experience


Master’s Degree and 6+ years of academic or industry experience


Ph.D. and 4+ years of academic or industry experience


Preferred Qualifications:

  • Ph.D. with 4+ years of industry relevant experience
  • Demonstrated record of productivity in organic or medicinal chemistry research as evidenced by publications and/or patents.
  • Independent, creative target design and high level of synthetic productivity applying modern synthetic methods with strong chemistry problem-solving skills.
  • A strong commitment to experimental work is expected, demonstrated by an ability to carry out multi-step syntheses and state-of-the art purifications, with spectroscopic characterizations of novel organic compounds (NMR, LC-MS, HPLC, etc.).
  • Proficient with Chemdraw, and other medicinal chemistry-related software.
  • Strong skills in gathering, documenting, and analyzing information from competitive sources such as patents and meetings and using this information to guide program strategy.
  • Emerging understanding of the drug discovery and development process.
  • A naturally collaborative and self-motivated style is necessary to work effectively in a fast-paced, highly integrated team environment.
  • Excellent written and oral communication skills, demonstrated ability to write peer reviewed quality work or invention disclosures for patent applications, and able to present the rationale, key data, issues and accomplishments department wide.


For California Sites -  The starting compensation for this job is a range from $121,000 - $167,2700, plus incentive cash and stock opportunities (based on eligibility). The starting pay takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation is decided based on demonstrated experience. For more on benefits, please visit our BMS Careers site. Eligibility for specific benefits listed in our careers site may vary based on the job and location.



If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.


Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.


On-site Protocol
Physical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.


COVID-19 Information
To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.


BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to Visit to access our complete Equal Employment Opportunity statement.


BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.


Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

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